Analytic Z-spectra water, CEST - pulsed spin-lock

Here you find analytic solutions of the Bloch-McConnell equations describing Z-spectra under pulsed spin-lock irradiation. This is the R_1ρ-based ISAR2-model as published in Roeloffs et al. (2014), NMR Biomed., 28, 40–53, doi: 10.1002/nbm.3192..

It is a very lean code to give you a tool illustrating the principal behaviour of a CEST effect and its interaction with the direct water saturation.

Download zipped Matlab implementations here or find the package on github.com/cest-sources/Z-pSL

Short Documentation

BATCH_Z_cw

First the pool parameters are defined in the parameter struct P:

%% SETUP 
%pool system parameters
%water pool A
P.R1A=1/3;          % longitudinalrelaxation rate [s^-1]
P.R2A=2;            % transversal relaxation rate [s^-1]
P.dwA=0; %deltaW_A in [ppm]

%CEST pool B
P.fB=0.001;         % proton fraction: [water protons]/[CEST agent protons]
P.kBA=200;          % exchange rate [s^-1]
P.dwB=1.9;          % (chemical shift) deltaW_B in [ppm} 
P.R2B=30;           % transversal relaxation rate [s^-1]

Now the CEST sequence parameters are defined

% sequence parameters
P.Zi=1;             % Z initial, in units of thermal M0, Hyperpol.: 10^4                  
P.FREQ=300;         % [MHz]  I use ppm and µT, therefore gamma=267.5153;
P.B1=2;             % [µT]
P.tp=5;             % pulse duration = saturation time [s]
P.xZspec= [-5:0.1:5]; % ppm

Now the function Z_cw(P) is called and plotted:

figure(32), plot(P.xZspec,Z_cw(P),'r-') ;   hold on;